Class Times: 10:30 - 11:55 AM, 121 Beckman Institute

Lecture Topics:

• Structure (1 lecture)
• Biogeochemical cycles (1)
• Electron transfer in proteins: Photosynthesis and Respiration (3)
• O₂ catalysis (oxygenases, oxidases) (3)
• Electron transfer in DNA (J. K. Barton) (1)
• Hydrogen, carbon, sulfur, nitrogen metabolism (3)
• Nitrogenase (D. C. Rees) (1)
• Metal Ion Storage and Transport (1)
• Radical Enzymes (1)
• Hydrolysis (1)
• Signaling and regulation (2)
• Metals in medicine (1)

Suggested References:

Bioinorganic Chemistry, Bertini, Gray, Stiefel, Valentine, Eds, University Science Books, 2007	Principles of Bioinorganic Chemistry, Lippard and Berg, University Science Books, 1994
SPECIAL ISSUE: Dioxygen Activation by Metalloenzymes and Models, Accts. Chem. Res., 2007, 40(7)	Long-Range Electron Transfer Special Feature, Proceedings of the National Academy of Sciences, USA, 2005, 102(10)
Bioinorganic Chemistry Special Feature, Proceedings of the National Academy of Sciences, USA, 2003, 100(7)

Molecular Viewing Programs:

• Pymol
• Discovery Studio Visualizer (free download, registration required)

Requirements and Grading:

• Oral presentation (20 min, 30 %) on a current topic in bioinorganic chemistry
• Original research proposal in bioinorganic chemistry (10 pages, 40 %)
• Team project on a problem related to bioinorganic chemistry (oral presentation by team members, 30 %)

Target Dates:

• April 16: Oral Presentation Topic Due
• May 2: First Draft of Research Proposal Due
• May 14: Project Selection Due
• May 23: Research Proposal Due
• May 30: Project Outline Due
• June 11, 13: Project presentations